With new research, gut immune cells travel to the brain, which affects Alzheimer’s development.
Alzheimer’s disease keeps the puzzle for doctors and researchers, but the new work is offering a different way of thinking about the development of the disease and how it can be treated in the future. A team at the Book Institute for Research on Aging has found that intestinal immune cells may have an important role in how the brain responds to Alzheimer’s. Their study, appeared in Cell reports On August 29, 2025, it shows that some of these gut immune cells are able to move into the brain, where they can affect inflammation and potentially affect the development of the disease. These results also show that diet, especially fiber -rich, can affect this process.
The intestine is the largest immune organ in the body, which has a variety of cells that usually protect against harmful bacteria and balance digestion. In this study, researchers looked at the mice to prepare Alzheimer’s. They discovered that a certain type of immune cell, called B cell, which usually helps maintain the balance of the intestines, has decreased in Alzheimer’s mice. Even more surprising was that some of these cells had left the intestines and traveled the brain, and the border was located in the region known as the Manangal Dora Meter. These guts were found derived from the immune cells to identify bacteria from the intestines, which increases the possibility that the gut and the brain are interacting in unexpected ways.
To understand why this movement is happening, scientists studied how the brain was calling these cells. He found that inflammatory cells in the brain of Alzheimer’s mice were developing a chemical signal that worked like a bacon, and encouraged the gut cells to migrate. Human data from past studies later confirmed similar patterns, which made the discovery even more compulsory. The team added a drug to prevent this signal in mice, which gave evidence that the “gut axis of the brain” could be manipulated.
Along with these results of the immune system, researchers have experienced whether the diet can help restore balance. They fed some of the mice to a fiber -rich substance, called Anulin. The results were promising: Gut B cells returned, and mice showed less weakness, including fewer earthquakes. The short chain manufactures fatty acids when the inflammatory breaks, which not only improves the health of the intestine but also travels to the body to affect other organs, including the brain. By reducing inflammation and improving intestinal balance, fiber provides benefits that have gone beyond digestion.
The team also noted that although fiber has not permanently reduced the brain plates-sticky reserves are often linked to Alzheimer’s-it has improved overall well-being. Mice remained healthy with a better score on several aging measures. This shows that even if the diet cannot eliminate the disease, it can still help to increase the quality of life. One of the researchers emphasized that these results support not only for general health but potentially mental flexibility, more than a longer advice on more fruits and vegetable eating.
The biggest question is whether these changes in the intestinal immune system are merely a reaction to mental damage due to Alzheimer’s or whether they help run the disease first. Some researchers believe that early signals may be protective, but over time, constant pressure weakened the gut, which increases harmful bacteria throughout the body and increases inflammation. If this is true, quick interference can prevent or slow down the disease process.
Future work will focus on whether specific gut bacteria can be tied to Alzheimer’s or other brain conditions such as Parkinson’s and multiple sclerosis. If some bacteria are associated with increased inflammation, then these signals can be designed to prevent treatment before damaging treatment. The main post documentary Fellow of this study expressed the hope that early intervention, whether through diet, drugs, or micro -bioche adjustment, could eventually change the direction of the disease.
For now, the discovery adds another piece to Alzheimer’s puzzle, which connects the intestines and the brain in a way that he expects. It also highlights the importance of everyday choice, such as eating more fiber, which can have far more far -reaching effects than once.
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