Researchers indicate the changes in the genes connected to the mysoteloma related to the asbestos, helping to detect initials.
For decades, the exposure to asbestos causes serious precision problems, especially a rare cancer called a deadly stroke. The disease affects the lung lining and is usually diagnosed in a late stage, making it difficult to treat. Although it is clear that the asbestos trigger is, scientists are working to understand how this cancer really is formed in the body. A recent study can help to show what happens at the microscope surface for gene changes, researchers find a clear picture of how asbestos damages cells over time.
The study was conducted by teams from Temple University in the United States and University of Italy. These researchers saw how genes behave in people with Mesotleuma because of the asbestos. They used a method of RNA setting to test which genes are on or off in patients with the disease. Statistics have come from public sources and have been allowed to compare the genes activity between healthy and cancer tissues. By doing so, they got a lot of genes that seem to work differently in people with Mesotleuma.
Some changes were found in how the cells handle stress and how they manage the ions – small particles that help with the basic cell functions. Other genes were attached to how the structure inside the cell is separated, which can occur when the asbestos fibers are breathed and lungs in the lung tissue. Over time, these fibers can harm the cells so badly that they begin to get out of control, causing cancer.
Although such genes research may seem complicated, the results of the real world may yield. If doctors know which genes are likely to change in front of the asbestos, they can first catch the disease. Right now, mesotheloma is often found only after the symptoms appear, which can occur decades after the exposure. It is difficult to treat this delay. But if scientists can develop tests based on genes changes found in this study, people at risk can be more closely monitored. Early detection can mean treatment and better results.
This study also contains the basis of a new type of treatment. Most of the cancer treatments are based on attack on rapidly distributing cells, which is a common feature of the tumor. But targeting specific genes that contribute to asbestas -related cancer, drugs can be more concentrated in the future. This will mean less side effects and potentially more effective treatment. For example, if one of the gene changes in how to handle the tumor stress, a drug can be prepared to further damage this weakness, which helps to kill cancer cells without damaging healthy tissue.
This work is made possible through the Italian workplace safety agency grant, which is appropriate because many mesotheloma cases come from job locations where asbestos was used heavy. Construction workers, shipyard employees, and others who have handled insulation content in the past are often affected. Since it takes so long to show the disease, new cases are still being diagnosed, though the use of asbestos has decreased in many places.
Although this research will not solve the problem overnight, it is a step ahead. The more scientists learn about how to replace the asbestos cells at the genetic level, as we get closer to the best tests, the first detection and treatment options. This new research includes another piece in the puzzle, which gives hope for those living with Mesotleuma and helps doctors produce better tools to fight it in the coming years.
Sources:
The study of the gene revealed the creep of mesotlooma linked to asbestos
From asbestos from the exhibition of carcinjinis: Transcromatic signatures in the deadly Fifophos Mesotlooma
