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    You are at:Home»Lifestyle»Mental Wellness»What Happens If You Miss One Dose of Antidepressants?
    Mental Wellness

    What Happens If You Miss One Dose of Antidepressants?

    newsworldaiBy newsworldaiOctober 21, 2025No Comments7 Mins Read0 Views
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    What Happens If You Miss One Dose of Antidepressants?
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    The key path

    • If you miss a dose of antidepressants, you may experience mild, short-term symptoms such as nausea and dizziness due to low levels of the medication in your body.
    • Take it as soon as you remember, unless it is close to the time of your next dose. Then just skip it and take your next dose as scheduled to avoid doubling up.
    • Taking your medication consistently and talking to your doctor before making any medication changes can help you avoid uncomfortable symptoms.

    Missing a dose of your antidepressant can cause flu-like symptoms such as upset stomach, discomfort and dizziness. These temporary symptoms are known as antidepressant withdrawal syndrome (ADS), which occurs when your body reacts to a sudden dip in medication levels. Although skipping a pill is usually not harmful, some people may feel stronger than others.

    Credit: Emma Kim/Getty Images
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    How missing a dose of antidepressants can affect you

    Missing a dose of Zoloft or another antidepressant may be enough to trigger withdrawal syndrome symptoms in some people. For many people, the symptoms of withdrawal syndrome may be mild enough, but others may find them particularly difficult to deal with. Some common symptoms include the following.

    • protest
    • anxiety
    • Blurred vision
    • It’s getting cold
    • Dizziness
    • Fatigue
    • headache
    • Indira
    • Irritability
    • Muscle pain
    • Nausea
    • Runny nose
    • sweating
    • Tingling sensations
    • Earthquakes
    • vivid dream

    Less common symptoms are:

    • Electric shock sensations
    • deception
    • High blood pressure
    • Lack of coordination

    How long do these symptoms last?

    Be assured that these symptoms:

    • are usually mild
    • It usually goes away within one to two weeks
    • If they become moderate or severe, they are easily treatable

    Why You May Have These Symptoms After Missing a Diet

    There are many different causes of dissociative syndrome. Here’s an overview of the most common causes of your symptoms.

    • Stopping your antidepressant suddenly: If you’ve been taking an antidepressant for a month or more and you suddenly stop taking it, you’re more likely to taper off slowly. It may take one to four days before you feel symptoms. For example, missing a Lexapro dose (or some dose) will cause you to start experiencing symptoms within the next few days.
    • Tapering too quickly from your antidepressant: A slow and gradual tapering schedule is important to prevent withdrawal symptoms, especially if you are taking a high dose or you are on an antidepressant for an extended period of time.
    • Skip a dose or two of your antidepressant: It’s estimated that 70 percent of people who take antidepressants skip a dose here and there. However, doing so increases your risk of developing withdrawal symptoms, especially if you are taking an antidepressant with a short half-life. These types are eliminated from your body so quickly that withdrawal symptoms appear quickly, sometimes within hours.
    • Change to a different configuration: Although it’s not common, if you’re switching from a brand-name antidepressant to a generic or from one generic to another by a generic company, the formulation may be different enough to experience formulation-related symptoms.

    Stopping suddenly or significantly and quickly reducing your dose of any type of antidepressant puts you at risk for withdrawal symptoms.

    The most common culprit seems to be immediate-release Effexor (venlafaxine) because it has a short half-life of three to five hours, and is most likely to cause these symptoms when you miss or miss a dose.

    Other common culprits of paradox syndrome include:

    • paxil (paroxetine)
    • pristiq (desvenlafaxine)
    • Zoloft (serterline)
    • Elvel (amitriptyline)
    • tofranil (imipramine)
    • All Monoamine Oxidase Inhibitors (MOUSE)

    How common are the symptoms?

    Research shows that about 70% of people who are prescribed occasionally miss doses. About 40% of those who suddenly stop taking their medication experience symptoms of antidepressant withdrawal syndrome.

    How to feel better after dieting

    Treatment of withdrawal syndrome may involve restarting the medication and then gradually tapering it. However, in some cases, people may be unwilling or unable to restart medication, especially if they experience severe or significant side effects.

    Discontinue syndrome and stiffness when taking Prozac (fluoxetine), so your doctor may recommend switching to this medication before you stop taking it.

    If restarting and tapering the medication is not an option, withdrawal symptoms will usually resolve within one to two weeks. The most severe symptoms often begin to improve within one to three days. During this time, supportive self-care can help people manage symptoms until recovery.

    How to prevent it from happening again

    So how can you prevent withdrawal symptoms from occurring?

    • First, don’t panic if you miss a dose of your antidepressant. It happens to the best of us.
    • Go ahead and take it as soon as you remember, unless it’s almost time for your next dose.
    • In this case, don’t double up; Just skip the missed dose and take your next dose as usual.

    Here are some other ways to prevent locking up syndrome.

    Take medicine on time

    The best way to avoid these symptoms is to be very careful to time your medication doses properly. Taking your medication as prescribed also makes it as effective as possible in treating your depression symptoms.

    A good way to make sure you take your medicine on time is to set an alarm in your calendar or clock on your smartphone or computer.

    If you’re not techie, consider using an old-fashioned alarm clock, write yourself a note, keep your medication where you can see it, set an alarm on your watch, and/or get a pill box for each day of the week.

    Think about switching

    If you’re finding it difficult to manage to take your medication on time, consider asking your doctor about trying a different antidepressant with a longer half-life or extended-release formulation so you don’t need to take it as often.

    For example, Prozac (fluoxetine) has a half-life of four to six days, so it takes longer to be completely cleared from your body than other antidepressants. This means that if you miss a dose, you are less likely to have withdrawal symptoms.

    Missing a dose of Prozac will result in fewer symptoms than missing a dose of Zoloft or Effexor.

    Talk to your doctor before stopping

    If you ever need to stop taking your antidepressant completely, you should always consult your doctor first.

    Never stop your antidepressant without your doctor’s knowledge.

    Depending on what you’re taking, how long you’ve been taking it, and the dose, they can help you avoid withdrawal syndrome by planning to slowly and gradually wean you off your medication.

    Does this mean I am addicted to antidepressants?

    Contradiction syndrome is quite common. Although many experts refer to this phenomenon as withdrawal, experiencing antidepressant withdrawal syndrome does not mean you are addicted.

    Antidepressants are rarely habit-forming and do not produce the cravings, euphoric effects, tolerance, or drug-seeking behavior seen with drugs of abuse. Another difference is that withdrawal syndrome symptoms are usually milder and last less time than illicit drug withdrawal symptoms.

    We take great care to use only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable and trustworthy.
    1. Gabriel M, Sharma V. CMA J. 2017 18 189(21):E747. doi: 10.1503/cmaj.160991

    2. Bhat V, Kennedy Sh. Recognition and management of antidepressant withdrawal syndrome. J Psychiatry Neurosci. 2017 42 42 (4): E7-E8. doi: 10.1503/jpn.170022

    3. Warner CH, Babu W, Warner C, Reid S, Rachel J. Am fame physician. 2006 74 74 (3): 449-456.

    4. Hensler J, Schmidt Y, Schmidt U, Schwarzer G, Bschort, Bethij C. Lancet Psychiatry. 2024 11 11 (7): 526-535. doi: 10.1016/S2215-0366(24)00133-0

    5. Bhat V, Kennedy Sh. Recognition and management of antidepressant withdrawal syndrome. J Psychiatry Neurosci. 2017 42 42 (4): E7-E8. doi: 10.1503/jpn.170022

    6. Wilson E, Leader M. A review of the management of antidepressant withdrawal symptoms. Ther adv Psychopharmacol. 2015 5 5 (6): 357-368. doi: 10.1177/2045125315612334

    Additional reading

    • Harvard Health Publishing. Get off antidepressants.

    • Hirsch M, Birnbaum RJ. Discontinuing antidepressant medications in adults. uptodate.

    By Nancy Schmalpfening

    Nancy Schmelfenning, MS is the administrator of the nonprofit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, and how devastating this experience of the illness itself can be.

    Thanks for your feedback!

    What is your opinion?




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